Photodynamic Cancer Therapy

What is photodynamic therapy?

Photodynamic therapy (PDT) is a treatment using a photosensitizing substance, and a particular type of laser light. Photosensitizers can form oxygen that kills nearby cells when exposed to a specific wavelength of light.

Various types of photosensitizer can be activated via the light of a specific wavelength. The wavelength, with its refractive index, dictates how far the light can travel into a body. Only until recently laser light could penetrate 1 to 2 cm into the body, but with the new technology, penetration can go very deep into the cellular structure. By combining specific photosensitizers and wavelengths of light, we can treat many different areas of the body with PDT.

Treatment costs

The treatment costs in our German affiliated clinic is about 16.000 to 18.000 Euros for a one-week treatment depending on the condition to be treated. For further details, please contact us.

The Principles of Photodynamic Cancer Therapy 

In the Video below, Dr. Weber explains the Principles of Photodynamic Cancer Therapy with his specific equipment.

How is PDT used to treat cancer?

To use PDT technology for cancer treatments, we have to inject a photosensitizing agent into the bloodstream. When the photosensitizer in the tumor is activated with the laser, it is absorbing the light and produces an energetic form of oxygen, which is destroying nearby cancer cells without side effects.

When most of the substance has left the healthy cells, usually after 24 to 72 hours, but still stays in cancer cells, the tumor is exposed to light. As the photosensitizer in the tumor absorbs the light and produces an active form of oxygen, it destroys nearby cancer cells without side effects.

Besides directly eliminating cancer cells, it appears that PDT also shrinks and destroy tumors in two other ways. The photosensitizer can not only damage blood vessels in the tumor, and with it is preventing cancer from receiving necessary nutrients, but PDT may also activate the immune system to support the fight against the tumor cells.

The video above explains the technology with low level laser light. In our treatment, we are using a specially developed Nanoparticle technology where the photosensitizer is embedded in liposomes. This is allowing the therapy with infrared light, able to penetrate deep into the body. PDT therapy is usually performed as an outpatient procedure, either alone or together with other treatments, such as surgery, radiation therapy or chemotherapy to support a cancer patient.

There is also the other type of PDT, the so-called extracorporeal photopheresis (ECP). ECP is a type of PDT in which a machine is used to collect the patient’s blood cells. The blood is then treated with a photosensitizing substance and exposed to light before returned to the patient.

ECP is approved by the U.S. Food and Drug Administration (FDA) as a tool to reduce the severity of skin symptoms of cutaneous T-cell lymphoma that has not responded to other treatments.

To determine, if ECP may have some application for other blood cancers, or to help to reduce rejection after transplants, various studies are underway, to investigate this possibility.

Photosensitizer Combination with Medical Laser Therapy

Because curcumin acts as a photosensitizer and also absorbs light in the blue range, it can be combined with a medical laser therapy very successfully. The rhizome of the medicinal plant Curcuma (Curcuma longa; turmeric), which belongs to the ginger family, is the raw material for curcumin. In India and Southeast Asia, Curcuma has been used in Ayurveda, one of the world's oldest medical systems, since thousands of years. Curcuma has shown an extremely diverse potential and can support the treatment of numerous medical conditions. It also contains phytonutrients (polyphenols)which have various health effects.

Ultrapure + Pro

Due to a particular protein binding, the UltraCur+ already had an extremely high bioavailability. Instead of a whey protein, The new version, not containing anymore a whey protein, contains N-acetylcysteine (NAC, ACC), which is a derivative of the naturally occurring amino acid cysteine. It is considered as an antioxidant with anti-inflammatory and detoxifying properties.

NAC is furthermore more quickly absorbed by the body, and easier to take, as 4 capsules of the former product UltraCur+ correspond to 1 capsule of the new PRO version. For a patient, this means a lower intake amount and an even better bioavailability. Besides this, in our experimental data, it showed that UltraCur+Pro could achieve a more than four times higher curcumin concentration in the plasma. This means that the absorption could also be improved with the new formula.

Suggested dose:
  1. Capsule a day: This supports preventive health now in the upcoming cold and flu season!
  2. Capsule a day: This is recommended to accompany existing therapies.
  3. Capsule a day: Recommended in Combination with Laser-Therapy (PDT)

The Ultrapure portfolio can be ordered via our partner website.

Curcumin even acts phototoxic in low concentrations (for example to bacteria), and also proapoptotic, anti-inflammatory, immune-stimulating, radioprotective, chemoprotective, antitumoral, antimetastatic, anti-angiogenetic, radiosensitizing and chemosensitizing. Thus, curcumin is considered a potent photosensitizer for PDT in the treatment of psoriasis, tumors, infections and other diseases.

The blue laser also improves microcirculation by releasing NO and has potent antibacterial and anti-inflammatory effects, which accelerate the healing process and helps to relieve pain.

CellularStem with its partner clinics in Germany is providing Photodynamic Cancer Therapy. For further details, please contact us.

Sources:

The National Cancer Institute, WeberMed