Diabetes

Diabetes

Diabetes is a medical condition that happens when a body is unable to regulate the blood sugar (glucose) concentration. The hormone Insulin, released by the pancreas helps the body to store and use the sugar and fat from the food we eat. Insulin is triggered by B-Cells when there is an increase in blood glucose. Diabetes can occur when the pancreas produces very little or no insulin because the B-Cells are dysfunctional.

There are basically two types of Diabetes. A person not able to produce Insulin are considered having Type 1 diabetes. This type of condition is an autoimmune disease. Here the body´s immune system, designed to fight infections, turn against a part of its cellular structure destroying the insulin-producing Beta-cells of the pancreas. Without insulin, cells are not able to absorb sugar from the fat and food we eat to produce the energy needed in our cellular structure, therefore we have to add insulin into a patient with such a condition.

In Type 2 diabetes, still considered by mainstream medicine as a metabolic disorder, also called non-insulin-dependent diabetes, a person´s cellular structure becomes resistant to insulin and is not able to use Insulin efficiently. Over time the pancreas may produce lesser insulin resulting in insulin deficiency. Since 2011 medical science is discussing the scientific indications that Type 2 diabetes is also as an autoimmune disease, which has consequences in the treatment of such a condition, because targeting the immune system mean’s a different treatment protocol than trying to control the blood sugar.

There is however also a third type of diabetes, called Gestational diabetes, this is when a pregnant woman, who have never had diabetes before, is developing a high blood glucose level during pregnancy, it may indicate the preceding development of type 2 diabetes.

The below video explains how the body is processing the food we eat in order to produce the energy needed in our cellular structure.

Symptoms
  • The symptoms for both types of diabetes are similar.
  • frequent urination
  • feeling very thirsty and drinking a lot
  • feeling very hungry
  • feeling very fatigued
  • blurry vision
  • cuts or sores that don’t heal properly

Often, the Symptoms of type 1 diabetes develop fast, typically over the course of several weeks and appear in childhood or adolescence, although it is possible to get type 1 diabetes later in life. Type 1 diabetes patients may unintentionally lose weight, and also experience irritability and mood changes.

Type 2 diabetes people often won’t have symptoms for many years as the disease develops slowly over the course of time until it is discovered like feeling numbness and tingling in their hands or feet.

Diabetes and obesity are somehow linked, the reasons why they are connected remain still unclear.

Uncontrolled diabetes can also damage the nervous system affecting legs and feet as a person may not feel heat, cold nor pain. This condition is called “sensory diabetes neuropathy.” As diabetes also affects the flow of blood, it takes longer for a sore or a cut to heal; this is called “peripheral vascular disease.”

If a person has an infection, that will not heal, because of weak blood flow, it is at risk for developing ulcers or gangrene, the development of dead body tissues, which may potentially result in amputations.

Treatment

Although there's no cure for diabetes, diabetes can be treated and controlled, and some people may go even into remission.

Traditional Treatment

To limit the impact on health, it is necessary to control the blood sugar levels, which may cause otherwise many serious health problems if not managed well. Weight management and frequent physical activity can support diabetes condition besides regular medication.

For diabetes type 1 patients it requires a treatment that keeps the blood sugar levels within a target range. The traditional treatment includes using an insulin pump or taking several insulin injections every day. To maintain the blood sugar level within the target range, it is necessary to monitor it several times a day.

Type 2 diabetes may be managed with non-insulin medications, weight reduction, or dietary changes.

Those traditional treatments do not address the cause of the problem that results in pancreatic ß cell dysfunction. New investigational treatment with stem cells has the objective to protect the remaining cells and replenish sufficient ß cells. This type of cellular therapy enables patients to reduce their insulin and hypoglycemic, i.e., the low blood sugar medications.

CellularStem Treatment Protocol
Basic procedure

In our associated clinic in India, we are treating diabetes patients with safe passage two, expanded mesenchymal stem cells from umbilical cord tissue via IV and injections in the Pancreas Artery.

The Cell treatment for Diabetics will require a minimum stay of three nights in Delhi. The costs for treating Diabetes with stem cells will depend on many factors including current health and the existence of any other underlying medical conditions. To pre-qualify for our stem cell treatment, our medical team has, therefore, to review the patient’s relevant medical information including the recent blood tests. Upon approval, a complete treatment plan will be provided. To learn more about the personalized treatment with expanded Mesenchymal stem cells, please contact us today with your medical details.

Treatment costs

Please note that treatment costs, besides the selection of treatment options, also is depending on the medical history and condition. For further details we suggest to complete our Patient Application Form, - see under contact - stipulating your condition and treatment request, and send it to our Delhi or Europe office. We actively strive to reply to any request either immediate or latest within two working days with details.
As a general guideline in respect of costs, the treatment cost for diabetes type 2 with a three-day stay in the hospital is in the range of 10.000 USD.

The treatment cost includes, besides the treatment, the stay in the hospital, in a family suite where the accompanying person will also stay. The medical review and analytical tests for the treatment at the hospital, the pick-up from and return to the airport to the hospital, an invitation letter from the hospital for the medical treatment for the visa application. Food for the patient is included during the hospital stay; the accompanying person may opt to take food at extra cost from the hospital or use nearby restaurants.
In case a patient and the accompanying person are interested in staying some days longer for a sightseeing tour our patient coordinator is happy to assist you. Flights and any additional treatments, besides the agreed stem cell treatment, or any stay in a hotel is not included in the above base price.

Quality of Stem Cells

Licensed physicians administer the stem cells intravenously (IV) and into the affected area. Stem cells may also be applied in certain circumstances, intrathecally and intramuscularly. Stem cells used are certified by the lab providing the cells to our partner clinics.

Medical Procedure Treatment

Stem cells treatment is performed as a medical procedure in a hospital setting which can bring improvement in metabolic control, Beta (ß) cell function, systemic inflammation, immunological regulation and an overall improvement in the quality of life. These improvements vary from patient to patient and cannot be guaranteed.

Side effects and Follow up

When it comes to side effects, our patients have not experienced serious side effects from the stem cells treatment, and we are monitoring the well-being of our patients in the first 24 to 48 hours by a dedicated patient coordinator.
Our stem cell treatment furthermore, does not end with the procedure in our partner clinics. We continuously care about how you are doing after you return home. Therefore, we will monitor your post-treatment progress on a regular basis. The proper follow-up, i.e., 1, 3, 6, 12, 24 months, to review the progress at the patient also helps us to evaluate the effectiveness of our investigational treatments and improve our protocols based on observed outcomes further.

Clinical Trials, Studies & General Information

Clinical Trial reviews December 2017. There are 12638 registered clinical studies reviewing drug-related Diabetes treatment. 99 Studies review the impact of stem cell treatment for Diabetes.

https://clinicaltrials.gov/ct2/results?cond=Diabetes+&term=&cntry=&state=&city=&dist=&Search=Search
https://clinicaltrials.gov/ct2/results?cond=Diabetes+and+stem+cells&term=&cntry=&state=&city=&dist=&Search=Search

DIABETES  - Stem Cell Research & Medical Publication
Kao, Der-I, and Shuibing Chen. 2012. Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes. Regenerative medicine, no. 4. doi:10.2217/rme.12.27. http://www.ncbi.nlm.nih.gov/pubmed/22817630.

DIABETES  - Stem Cell Research & Medical Publication
Hepatocyte Growth Factor Modification Promotes the Amelioration Effects of Human Umbilical Cord Mesenchymal Stem Cells on Rat Acute Kidney Injury  https://www.ncbi.nlm.nih.gov/pubmed/20446811

DIABETES  - Stem Cell Research & Medical Publication
Sacks, Frank M, Michel P Hermans, Paola Fioretto, Paul Valensi, Timothy Davis, Edward Horton, Christoph Wanner, et al. 2013. Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries. Circulation, no. 9 (December 18). doi:10.1161/CIRCULATIONAHA.113.002529. http://www.ncbi.nlm.nih.gov/pubmed/24352521.

DIABETES  - Stem Cell Research & Medical Publication
Sukpat, Supakanda, Nipan Isarasena, Jutamas Wongphoom, and Suthiluk Patumraj. 2013. Vasculoprotective effects of combined endothelial progenitor cells and mesenchymal stem cells in diabetic wound care: their potential role in decreasing wound-oxidative stress. BioMed research international (June 17). doi:10.1155/2013/459196. http://www.ncbi.nlm.nih.gov/pubmed/23844362.

DIABETES  - Stem Cell Research & Medical Publication
Salama et al. 2010 (Cell Transplant). Autologous hematopoietic stem cell transplantation in 48 patients with end-stage chronic liver diseases.
Cell Transplant. 2010;19(11):1475-86. doi: 10.3727/096368910X514314. Epub 2010 Jun 29.
https://www.ncbi.nlm.nih.gov/pubmed/20587151

DIABETES  - Stem Cell Research & Medical Publication
Khan et al. 2008 (Transplant Proc). Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure: a preliminary study.
Transplant Proc. 2008 May;40(4):1140-4. doi: 10.1016/j.transproceed.2008.03.111.
https://www.ncbi.nlm.nih.gov/pubmed/18555134

DIABETES  - Stem Cell Research & Medical Publication
Zhao, Yong, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Huimin Zhou, Zhaohui Yin, et al. 2013. Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial. BMC medicine (July 9). doi:10.1186/1741-7015-11-160. http://www.ncbi.nlm.nih.gov/pubmed/23837842.

DIABETES  - Stem Cell Research & Medical Publication
Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes. Vija L1, Farge D, Gautier JF, Vexiau P, Dumitrache C, Bourgarit A, Verrecchia F, Larghero J. DOI: 10.1016/j.diabet.2008.10.003 https://www.ncbi.nlm.nih.gov/pubmed/19230736

DIABETES  - Stem Cell Research & Medical Publication
Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer
Yue CaoXiaokun GangChenglin Sun, and Guixia Wang
Journal of Diabetes Research - Volume 2017 (2017), Article ID 9328347, 10 pages

https://doi.org/10.1155/2017/9328347

DIABETES  - Stem Cell Research & Medical Publication
The role of stem cells in the treatment of diabetic foot ulcers
Blumberg, S.N.; Berger, A.; Hwang, L.; Pastar, I.; Warren, S.M.; Chen, W.
Volume 96, Issue 1, pp. 1-9
https://www.journals.elsevier.com/diabetes-research-and-clinical-practice/free-most-downloaded-articles/stem-cells-in-the-treatment-of-diabetic-foot-ulcers

DISCLAIMER

Like with all related biological treatments there is no guarantee that stem cell treatments, even though showing good results in individual cases, will provide the envisioned improvements with our investigational, patient funded treatment therapy. Long termed improvements sometimes have been achieved with multiple treatments with either allogeneic or autologous stem cells expanded and cryo-preserved, permitted in our associated Indian clinic.